Presence of Mono-Oligoclonal Rearrangement of V5-J5 TCR Genes in Myasthenia Gravis
نویسندگان
چکیده
Rearrangement of T cell receptor (TCR) V8-J8 genes has been analyzed in 20 myasthenia gravis (MG) cases and 17 controls (blood donors) using the seminested polymerase chain reaction (PCR). Unlike the healthy subjects the majority of patients demonstrated a monoor oligoclonal type of rearrangement of TCR V51-6-J51 genes. It is suggested that T lymphocytes may undergo clonal expansion in myasthenia gravis due to stimulation by an autoantigen related to myasthenia pathogenesis. The results strongly argue for a significant role of the y/5 T cells.
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